Abstract:Intestine plays an important role in fish health as it can absorb nutrients and defend against pathogens,microbes and bacterial toxins entering the internal environment.As the organ with the largest contact area between fish and the external environment,the intestine is invaded by many factors,which seriously restricts the healthy growth of fish.This article reviewed the intestinal tissue structure, intestinal barrier function,factors that cause intestinal damage and substances that could effectively alleviate intestinal damage in fish,in order to provide certain theoretical basis for protecting fish intestinal health and promoting the healthy development of aquaculture industry.